Trial Forge • A systematic way to improve trial efficiency

Trials

Randomised controlled trials are the gold standard for evaluating healthcare treatments; 1000s are done every year.

Essential

Randomised trials are the cornerstone of evidence-based healthcare because they offer the fairest tests of treatments, therapies and initiatives.

Inefficient

The evidence base for how to make the trials process efficient is remarkably thin. Trial Forge aims to change this.

Small Changes add up

Large, single improvements are nice to have but rather rare. Marginal gains – small improvements to processes – start to add up if look across a whole system. Trial Forge aims to look across all trial processes with the intention of trying to improve them all, even if it’s just by a tiny amount, because these gains will start to add up when done across the whole trial system.

Trial Forge will make trials more efficient by looking for marginal gains across all trial processes, from research question to implementation into routine care. It will encourage everyone connected with trials to be more sceptical of what we do by asking for the evidence behind all of our trial decisions.

While the research questions and ideas can be novel and ambitious, some of the more challenging questions can often be found in teasing out the methodological issues that surround a clinical trial.

In the context of clinical trials, ‘‘quality’’ can be generally defined as the absence of errors that matter to decision-making—that is, errors which have a meaningful impact on the safety of trial participants or the credibility of the results (and thereby the care of future patients). (Clinical Trials. 2016 Apr 20.)

Researchers research so that we as patients and our clinicians can have better conversations

If research was a transport business, we would be appalled by these data. Half the goods carried would be badly designed, half lost in shipping, and half of the remainder broken by the time they arrived—a truly heart breaking waste.

Supposing is good, but finding out is better.

There is a peculiar paradox that exists in trial execution - we perform clinical trials to generate evidence to improve patient outcomes; however, we conduct clinical trials like anecdotal medicine. (Heart Fail Review 2012; 19: 135-52)

There are a lot of observational studies on recruitment. Are they useful? Hard to say, though I aim to find out. If they turn out to provide little to guide recruitment decisions, we should stop doing them, or they effectively become a recurring example of research waste.

LATEST NEWS & EVENTS

Funding to test the effectives of monetary incentives for recruitment and retention

February 14, 2025

A list of 11 priority recruitment and retention SWATs

February 9, 2024

Studies Within A Trial (SWATs) are a good way of generating evidence to support trial process decision-making. SWATs are designing to be replicated, which means it's important to have some focus otherwise we end up [...]

Resources to help with the design and delivery of SWATs

January 10, 2024

The Trial Forge SWAT Centre (University of York) in conjunction with the Trial Forge SWAT Network have recently been working to develop resources on the design and delivery of Studies Within A Trial (SWATs). These [...]

LATEST RESOURCES

Protocols and resources for priority recruitment and retention SWATs (PRESS)

The ‘Protocol and resource development for prioritised recruitment and retention strategies’ (PRESS) project aimed to develop these protocols, and resources,

Resource Type: Guidance, SWAT Bundles

Date Posted: April 1, 2025

Trial Forge Guidance 2: Value of Information Tool

Trial Forge Guidance 2 helps trial teams decide if another SWAT is needed to answer an existing research question. Five

Resource Type: Guidance

Date Posted: March 5, 2025

Guidance– Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups—practical guidance to support better practice

Randomised trials, especially those intended to directly inform clinical practice and policy, should be designed to reflect all those who

Resource Type: Guidance

Date Posted: January 24, 2024